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Buy chenodiol tablet online, film coatedRetrophin, TABLETS) 250 MGSPECIAL NOTEB ecause of the potential hepatoxicity of chenodiol, poor response rate in some subgroups of chenodiol treated patients, and an increased rate of a need for cholecystectomy in other chenodiol treated subgroups, chenodiol is not an appropriate treatment for many patients with gallstones. Chenodiol should be reserved for carefully selected patients and treatment must be accompanied by systematic monitoring for liver function alterations. Aspects of patient selection, response rates and risks versus benefits are given in the insert.
Buy chenodiol tablet online henodiol is the non-proprietary name for chenodeoxycholic acid, a naturally occurring human bile acid. It is a bitter-tasting white powder consisting of crystalline and amorphous particles freely soluble in methanol, acetone and acetic acid and practically insoluble in water. Its chemical name is 3α, 7α-dihydroxy-5β-cholan-24-oic acid (C24 H40 O4 ), it has a molecular weight of 392.58, and its structure is shown below;Its chemical name is 3α, 7α-dihydroxy-5β-cholan-24-oic acid (C24H40O4), it has a molecular weight of 392.58, and its structure is shown below;Chenodiol film-coated tablets for oral administration contain 250 mg of chenodiol.Inactive ingredients: pregelatinized starch; silicon dioxide; microcrystalline cellulose, sodium starch glycollate; and magnesium stearate; the thin-film coating contains: opadry YS-2-7035 [consisting of methylcellulose and glycerin] and sodium lauryl sulfateCLINICAL PHARMACOLOGYAt therapeutic doses, chenodiol Buy chenodiol tablet online without prescription suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Chenodiol has no effect on radiopaque (calcified) gallstones or on radiolucent bile pigment stones.INDICATIONS AND USAGEChenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. The likelihood of successful dissolution is far greater if the stones are floatable or small. For patients with nonfloatable stones, dissolution is less likely and added weight should be given to the risk that more emergent surgery might result form a delay due to unsuccessful treatment. Safety of use beyond 24 months is not established. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.DOSAGE AND ADMINISTRATIONThe recommended dose range for Chenodiol is 13 to 16 mg/kg/day in two divided doses, morning and night, starting with 250 mg b.i.d. the first two weeks and increasing by 250 mg/day each week thereafter until the recommended or maximum tolerated dose is reached. If diarrhea occurs during dosage buildup or later in treatment, it usually can be controlled by temporary dosage adjustment until symptoms abate, after which the previous dosage usually is tolerated. Dosage less than 10 mg/kg usually is ineffective and may be associated with increased risk of cholecystectomy, so is not recommended.HOW SUPPLIEDChenodal� (chenodiol tablets) is available as white film-coated 250 mg tablets imprinted “MP” on one side and “250″ on the other in bottles of 100,
How to use Chenodiol Tablet
Dosage is based on your medical condition, weight, and response to treatment.
Aluminum-containing antacids and certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol) can decrease how much of this medication your body absorbs. If you are taking any of these medications, separate them from chenodiol by at least 4 hours.
To reduce your risk of side effects such as diarrhea, your doctor will direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Tell your doctor if you have severe diarrhea. Your doctor may need to lower your dose or stop the medication.
Do not increase your dose or take this medication more often without your doctor’s approval. Your condition will not improve any faster, and the risk of serious side effects may be increased.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not stop taking this medication without talking with your doctor.
It may take up to 24 months before the gall stones are completely dissolved. Your doctor will order tests (gall bladder sonograms or x-rays) to check your progress. Keep all medical appointments. Tell your doctor if your condition persists or worsens (stomach/abdominal pain, nausea, or vomiting).
Buy chenodiol tablet online without prescription Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This drug may cause serious (possibly fatal) liver disease. Your doctor will order blood tests to check for liver problems. It is very important to keep all lab appointments. Seek immediate medical attention if you have any symptoms of liver damage, including: yellowing eyes/skin, dark urine, unusual/extreme tiredness, severe stomach/abdominal pain, persistent nausea/vomiting.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Buy chenodiol tablet online Before taking chenodiol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as hepatitis, cirrhosis), a certain red blood cell problem (hemolysis), regular use/abuse of alcohol.
This medication must not be used during pregnancy. It may harm an unborn baby. Estrogen-containing birth control may increase your risk of gall stones. Discuss the use of reliable forms of birth control with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.
Buy chenodiol tablet online The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.
Buy chenodiol tablet online without prescription ,To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor’s approval.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.